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Themed Short Track July/August 2019
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Introducing Themed Short Tracks

In SHORT TRACKS we collect 2-4 recent lectures from EAS congresses or courses, putting them together to provide up-to-date perspectives on a given current topic.

This month’s SHORT TRACK topic is “Causality and pathogenesis of non-lipid and lipid risk factors”. Under this headline, we have selected two presentations given at the EAS Advanced courses in Copenhagen and in Vienna 2018

                     To the SHORT TRACK “Causality and pathogenesis of non-lipid and lipid risk factors” >>

These presentations are open for EAS members only. Register as an EAS Individual member, and the whole ACADEMY is open for you.

                                                                                                         How to register as an EAS member >>

What have Mendelian randomization studies revealed for cardiovascular disease beyond lipids

This presentation was given as a lecture by Professor Marianne Benn, University of Copenhagen. Professor Benn is an internationally recognized expert in lipoprotein metabolism, genetics, and Mendelian randomization studies.
In her lecture, Professor Benn first described the concepts of Mendelian randomization, the pitfalls and assumptions, and how we can use it to qualify biological pathways as drug targets.
Secondly, she gave an overview of the causal evidence for non-lipid risk factors for cardiovascular disease. She concluded by stating that the use of genetic data from human studies, in the form of individual level data from large cohort studies of the general population or as summary level data from genetic consortia, will increase the validity of pathways and risk factors for drug development, and public health recommendations

                                                                                                            To the presentation>>

 LDL retention

This presentation was given as a lecture by Professor Jan Borèn, University of Gothenburg. Professor Boren has a particular interest in lipids and lipoproteins that are direct causes of atherosclerotic cardiovascular disease and has contributed over the last decades to our understanding of how lipoprotein particles internalize in the arterial all.

First, Professor Borèn outlined the overwhelming evidence from epidemiology, clinical trials, genetics, and experimental research that low-density lipoprotein cholesterol (LDL-C) is causal for the development and progression of atherosclerotic cardiovascular disease.
Secondly, he gave an overview of the pathogenesis of LDL cholesterol particles, how they enter the arterial wall, attach to proteoglycans, aggregate, and accumulate into atherosclerotic plaques. Professor Borèn concluded that atherosclerosis is a longterm dynamic process that both depends on the plasma concentration and features of the lipoproteins, and also on the responses and characteristics of the artery wall. Perspectives may be that we in the future will be able to give a more precise treatment tailored to the individual patient taking into account both the level of LDL cholesterol and features of the LDL cholesterol particle and of the arterial wall.

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