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Themed Short Track May-June 2020
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Introducing Themed Short Tracks

In SHORT TRACKS we collect 2-4 recent lectures from EAS congresses or courses, putting them together to provide up-to-date perspectives on a given current topic.

This month’s Short Track topic is “Prediction of CVD – genes and risk factors”. Under this headline, we have selected two presentations given at the EAS Congress in Maastricht 2019.

                     To the SHORT TRACK Prediction of CVD – genes and risk factors >>

These presentations are Open Access for members and non-members.                                                                          

EAS ACADEMY

The genetic burden in CVD

This presentation was given as a lecture by Heribert Schunkert, Professor in Cardiology of the Technische Universitaet Munich, Director of the Cardiology Department and Medical Director of the German Heart Centre Munich. 
Professor Schunkert is a pioneer within genome-wide association studies (GWAS) in cardiovascular disease (CVD) with the initiation of the CardioGram genetics consortium. 

In his lecture, professor Schunkert first described monogenic disorders versus polygenic traits, and stated that the “common variant-common disease” hypothesis has proven right based on the accumulating evidence from a wealth of GWAS projects. 

Monogenic disorders as Familial Hypercholesterolemia is important for individual risk, however common variants have more profound effects at the population level, since all individuals carry a spectrum of risk alleles.
At present 164 genomic loci associated with CVD have been identified and involves mechanisms within blood pressure, lipid metabolism, neovascularization, angiogenesis, inflammation, transcriptional regulation, nitric oxide signaling and vascular remodeling.
Most interestingly, genome-wide polygenic risk scores identify individuals with risk equivalent to monogenic diseases like Familial Hypercholesterolemia.

The near future will show whether polygenic risk scores have a place in risk prediction and prevention.

To the presentation >>

Estimating risk – what’s new?

 

This presentation was given as a lecture by Ian Graham, Professor of Cardiovascular Medicine in Trinity College, Dublin, and Professor Emeritus of Preventive Cardiology at the Royal College of Surgeons in Ireland. Professor Graham has been a driving force in generation and recalibration of the SCORE risk charts for decades. The SCORE system has now been recalibrated to cover a spectrum of European, Asian and middle east countries by taking the specific underlying risk factor patterns and underlying risk factor patterns and underlying incidences of CVD for each country or region into account.

 

Professor Graham gave an overview of the future directions and ideas on how to improve risk prediction incorporating life-time risk and estimates from genes. Mendelian randomization strategies shows that 1 mmol/L lower lifetime LDL cholesterol decreases CVD risk by 50-55%, information that in the near future may be incorporated into the SCORE system.

To the presentation>>

 

 

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