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Sarah Jane George

Biography

After studying at the University of Wales College of Medicine, Sarah started her academic career at the University of Bristol in 1994. She became Professor of Cardiovascular Signalling in 2010 and is currently Head of Department of Translational Health Sciences and Deputy Head of the Medical School. 
Sarah was the Chair of the British Atherosclerosis Society from 2014-2017. Her research has extended the understanding of key proteases (matrix-degrading metalloproteinases, MMPs) in vein graft failure and evaluated novel gene therapy and synthetic inhibitors approaches to reduce vein graft failure. Sarah’s research focuses on the role of cadherin-mediated cell:cell contact and associated Wnt/β-catenin signaling pathways in cardiovascular diseases including atherosclerosis, restenosis and aneurysms. Her research group aims to understand how cell:cell contact and Wnt signaling affects processes involved in vein graft failure, atherosclerosis, aneurysm and post-MI remodeling with the aim of developing novel therapeutic approaches to improve patient outcome. Her research extends to examining the development of novel conduits for bypass grafting. 
Sarah utilizes a number of in vitro, ex vivo and small and large animal in vivo models, as well as unique Biobanks, in Bristol to perform this potentially translational research that could benefit patients with cardiovascular disease. 
Her involvement in translational research and desire to teach and inspire researchers of the future have motivated her to develop and act as Director of two MSc programmes (MSc Translational Cardiovascular Medicine and MSc Perfusion Science both of which utilize unique e-learning approaches).

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