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Focus on EAS Innsbruck 2016: Introducing the faculty - Plenary speaker Teri A. Manolio

Tuesday 10 November 2015   (0 Comments)
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A forward-looking scientific Programme to excite, inspire and inform!

The EAS 2016 Scientific Committee has created a programme featuring ground-breaking speakers in their respective fields. EAS 2016 Innsbruck welcomes a distinguished international faculty to share their forward-looking perspectives on the latest developments in basic research and clinical practice in atherosclerosis and cardiovascular disease. You can find details of the Plenary and Workshop sessions now on the Congress website,

Abstract submission is now open. Submit your abstract by January 11, 2016 for the opportunity to present your findings at this prestigious international Congress.

Here, in a series of newsletters, we introduce members of the EAS 2016 Innsbruck faculty.

Plenary session 1, Monday, May 30, 2016: Integrative approach in atherosclerosis

Teri A. Manolio, USA: Leading the way to genetics and pharmacogenomics in the clinic

Teri A. Manolio is Director of the Division of Genomic Medicine, National Human Genome Research Institute, Rockville, Maryland, Professor of Medicine at the Uniformed Services University of the Health Sciences, and is a practicing clinician at the Walter Reed National Military Medical Center, Bethesda. She completed undergraduate training at the University of Maryland, and her PhD in human genetics and genetic epidemiology at the Johns Hopkins School of Hygiene and Public Health. Dr Manolio was previously at the National Institute of Health National Heart, Lung, and Blood Institute where she was involved in large-scale cohort studies such as the Cardiovascular Health Study and the Framingham Heart Study. Her research interests focus on genome-wide association studies of complex diseases, ethnic differences in disease risk, integrating genomic research into electronic medical records, and incorporating genomic findings into clinical care.

Genome-wide association studies, DNA sequencing studies and other genomic studies are identifying an increasing number of genetic variants associated with clinical phenotypes that have application in diagnosis, and preventive and treatment strategies. The implications of this shift in clinical medicine are enormous, not only for physicians but also for healthcare systems and policy makers, who have to deal with the cost, logistics, new technologies and ethics of transitioning to an era of personalised care.

To date, translation of such knowledge to routine clinical practice has been limited. A key reason has been the lack of an accessible comprehensive evidence base for clinicians. The advent of integration of genome-scale analysis into clinical care necessitates new thinking on approaches to collecting and characterising data on the clinical implications of genetic variants, developing consensus for their application, and improving the accessibility of such information to clinicians.

To address these multiple challenges, the National Human Genome Research Institute has initiated research programmes involving next-generation sequencing in the management of polygenic conditions, workup of undiagnosed conditions, and identification of variants associated with clinical phenotypes. Additionally, the development of educational materials for healthcare personnel working to implement the use of genomic findings in clinical care is also a priority. Collaboration between genetics researchers, data analysts, clinicians and medical institutions, professional societies and regulatory agencies will be critical to addressing the challenges posed by the pharmacogenomics era. Ultimately these complementary actions will ensure the transition of genomics from the bench to the bedside.


Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, Balling R, Berger AC, Bleyl S, Chakravarti A, Chantratita W, Chisholm RL, Dissanayake VH, Dunn M, Dzau VJ, Han BG, Hubbard T, Kolbe A, Korf B, Kubo M, Lasko P, Leego E, Mahasirimongkol S, Majumdar PP, Matthijs G, McLeod HL, Metspalu A, Meulien P, Miyano S, Naparstek Y, O'Rourke PP, Patrinos GP, Rehm HL, Relling MV, Rennert G, Rodriguez LL, Roden DM, Shuldiner AR, Sinha S, Tan P, Ulfendahl M, Ward R, Williams MS, Wong JE, Green ED, Ginsburg GS. Global implementation of genomic medicine: We are not alone. Sci Transl Med 2015;7:290ps13.

Feero WG, Manolio TA, Khoury MJ. Translational research is a key to nongeneticist physicians' genomics education. Genet Med 2014;16:871-3.

Manolio TA, Murray MF; Inter-Society Coordinating Committee for Practitioner Education in Genomics. The growing role of professional societies in educating clinicians in genomics. Genet Med 2014;16:571-2.

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